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CBD Oil Skin Care in LotionStem cells have recently become a huge buzzword in the skincare world. But what does this really mean? Skincare specialists are not using embryonic stem cells; it is impossible to incorporate live materials into a skincare product. Instead, companies are creating products with specialized peptides and enzymes or plant stem cells which, when applied topically on the surface, help protect the human skin stem cells from damage and deterioration or stimulate the skin's own stem cells. Stem cells have recently become a huge buzzword in the skincare world. But what does this really mean? Skincare specialists are not using embryonic stem cells; it is impossible to incorporate live materials into a skincare product. Instead, companies are creating products with specialized peptides and enzymes or plant stem cells which, when applied topically on the surface, help protect the human skin stem cells from damage and deterioration or stimulate the skin's own stem cells. National Stem Cell was one of the few companies who actually incorporated into their skin care an enzyme secreted from human embryonic stem cells, but they are in the process of switching over to use non-embryonic stem cells from which to take the beneficial enzyme. Stem cells have the remarkable potential to develop into many different cell types in the body. When a stem cell divides, it can remain a stem cell or become another type of cell with a more specialized function, such as a skin cell. There are two types of stem cells, embryonic and adult. Embryonic stem cells are exogenous in that they are harvested from outside sources, namely, fertilized human eggs. Once harvested, these pluripotent stem cells are grown in cell cultures and manipulated to generate specific cell types so they can be used to treat injury or disease. Unlike embryonic stem cells, adult or multipotent stem cells are endogenous. They are present within our bodies and serve to maintain and repair the tissues in which they are found. Adult stem cells are found in many organs and tissues, including the skin. In fact, human skin is the largest repository of adult stem cells in the body. Skin stem cells reside in the basal layer of the epidermis where they remain dormant until they are activated by tissue injury or disease. 1 There is controversy surrounding the use of stem cells, as some experts say that any product that claims to affect the growth of stem cells or the replication process is potentially dangerous, as it may lead to out-of-control replication or mutation. Others object to using embryonic stem cells from an ethical point of view. Some researchers believe that the use of stem cell technology for a topical, anti-aging cosmetic trivializes other, more important medical research in this field. The skin stem cells are found near hair follicles and sweat glands and lie dormant until they "receive" signals from the body to begin the repair mode. In skincare, the use of topical products stimulates the stem cell to split into two types of cells: a new, similar stem cell and a "daughter" cell, which is able to create almost every kind of new cell in a specialized system. This means that the stem cell can receive the message to create proteins, carbohydrates and lipids to help repair fine lines, wrinkles and restore and maintain firmness and elasticity.1 First to the market in Britain in April 2007 and the U.S. was ReVive's Peau Magnifique, priced at a staggering £1,050. Manufacturers claim it uses an enzyme called telomerase to "convert resting adult stem cells to newly-minted skin cells' and 'effectively resets your skin's "ageing clock" by a minimum of five years'. The product claims long-term use 'will result in a generation of new skin cells, firmer skin with a 45 per cent reduction in wrinkles and increased long-term skin clarity'. Peau Magnifique is the latest in a line of products developed by Dr Gregory Bays Brown, a former plastic surgeon. In the course of his research into healing burns victims, Dr Brown discovered a substance called Epidermal Growth Factor (EGF) that is released in the body when there is an injury, and, when applied to burns or wounds, dramatically accelerates the healing process. He believed the same molecule could be used to regenerate ageing skin and went on to develop ReVive, a skincare range based around it. 2 Hot on the heels of Peau Magnifique was Amatokin by Voss Laboratories. Amatokin was marketed by the same people behind the StriVectin craze and launched exclusively at Bloomingdale's. Amatokin works by stimulating the adult stem cell reservoirs in our skin to help rejuvenate it. From the day we are born, our skin experiences the incremental and cumulative effects of intrinsic and extrinsic aging. When we are young, stem cell utilization for skin rejuvenation functions efficiently. As we age, it reduces significantly. Given the proper environment, these inherent stem cell reservoirs can be stimulated to renew the skin. 3 Studies show that aging and damage from UV rays and pollution cause a decrease in stem-cell production. Pincelli and LVMH laboratories in 2008 identified key ingredients with the ability to protect the stem cells from external factors and produced Dior's Capture R60/80 XP In lab tests, skin samples collected from cosmetic-surgery patients showed more stem cells in the areas where cream had been applied. because it protects existing stem cells from damage, not because it increased the number of stem cells.. Says Dr. Pincelli 'That power is absolutely vital for epidermal regeneration and for maintaining the skin's youthful appearance'. 4 According to Petrikovsky, fetal skin heals in a completely different way to adult "Adult skin heals via an inflammatory response, involving macrophages and type 1 collagen. On the other hand, fetal skin, when it is healing, relies heavily on the skin's stem cells and fibroblasts". One of the most important differences between adult and fetal skin is the fact that fetal skin heals without scarring. A wrinkle is a small wound, For this reason Petrikovsky has been looking at ways we can activate the adult stem cells in the skin to perform in similar ways to those in fetal skin. One substance he has found that can upregulate the stem cell activity of adult skin is Peptide 199, an amino acid chain derived from the Wharton Jelly, a gelatinous substance found in the umbilical cord. This upregulation ensures the fibroblast dominance over the inflammatory process during skin repair, mimicking the process that occurs in fetal skin, healing without a scar or wrinkle.5 Emerge Labs new Swiss Apple Stem Cell Serum allows plant stem cells to preserve and protect skin stem cells. Hempgeix® - a novel plant cell culture technology has been invented to cultivate dedifferentiated callus cells from a rare Swiss apple. These apple stem cells are rich in epigenetic factors and metabolites, assuring the longevity of skin cells. The Skin Stem Cell Serum protects longevity and combats chronological aging while delaying senescence of skin cells, preserving the youthful look and vitality of one's skin. The Institute for Biotechnological Research (IRB) has released an anti-aging ingredient based on edelweiss stem cells. "As edelweiss grows in harsh climates it is obliged to produce a number of active substances that help protect against the elements such as UV rays," IRB's Francesca Melandri says. The edelweiss active harnesses the protective substances the plant uses to defend itself against harsh climatic and environmental conditions and uses them to protect the skin,. According to the Italian company. the ingredient, Leontopodium alpinum stems, has high concentrations of leontopodic acids A and B which have strong antioxidant properties. IRB also claims the product has strong anti-collagenase and hyaluronidase actvity, therefore helping to limit the degradation of collagen and hyaluronic acid in the skin. The company uses what it refers to as its HTN technology to produce the ingredients in industrial quantities. A small amount of plant biomass is chopped into tiny pieces and placed in a culture medium. Damaging the plant in this way causes the cells that surround the damage to de-differentiate (to turn back into stem cells) and form a wound healing tissue called the callus. The callus is then harvested and grown in a cell culture medium and from this IRB obtains the plant stem cells and consequently the secondary metabolites they need for their products. Although the technology is well known, the challenge lies in successfully scaling up the production of the stem cells to industrial quantities - a problem IRB claims to have solved with its HTN technology. 6 Hempgeix® Stem Cell CBD Skin Care has come out with its Cell Renewal Night Cream, Reset Serum, Cell Rebuilding Daytime Cream, and Repair Eye Contour Cream According to the company, Hempgeix® Stem Cell CBD Skin Care Stem Cell Technology uses active plant cells from rare, 100% organic, nutrient-rich plants to create new cells of the highest in purity and nutrients. These new cells are able to deliver high concentrations of lipids, proteins, amino-acids and phytoalexins. They are easily absorbed into the outermost cells of the epidermis, allowing for almost immediate skin cell renewal, nutrient absorption, and an increase in the skin's level of filaggrin proteins. According to the company, "conventional plant cell extraction is only able to obtain these nutrients in smaller and far less potent quantities. Traditional plant cell cloning uses harsh chemicals or pollutants to reproduce active cells. Hempgeix® Stem Cell CBD Skin Care products are made from cloned stem cells from the date palm, chosen for cloning because of its unparalleled ability to live and thrive in the desert in the driest, most arid areas and be able to remain hydrated and conserve water. Xtemcell cloned these desirable properties and created a series of age-maintenance skincare products that contain 100% organic stem cells that promote a superior moisturization of the skin. National Stem Cell is pursuing a different route to younger looking skin. It's subsidiary Decouverte Cosmetique is producing anti-aging products that incorporate tropelastin secreted from human embryonic stem cells. National Stem Cell changed its name to Proteonomix a month after launching a stem cell based cosmeceutical line in Aug 2008.7 The company claims the ingredient enhances the natural formation of collagen and binds with existing protein chains in the skin to make it appear smoother and firmer. Tropelastin already affects skin appearance naturally in pregnant women. The inspiration for the products came from the natural glow of women post-conception, caused by the release of the chemical from embryonic stem cells. The company says that the products escape the health risk warning flags out because they do not affect the growth of stem cells. However, the products formulated by Decouverte Cosmetique may be particularly controversial from an ethical or moral point of view because the active ingredient is sourced from human embryonic stem cells. However, National Stem Cell says that all the stem cells used were harvested before 2001 and none were destroyed or created in the development of the products. The company is also in the final stages of discovering how to source the key material from non-embryonic stem cells thereby weakening the ethical barrier to commercialization. 8 Thus we can see that there are already many choices in skin care products with specialized peptides and enzymes or plant stem cells which, when applied topically stimulate the skin's own stem cells. Expect many more good choices to be developed in the years to come!
CBD Anti Aging LotionAs we age, the reduced turnover of our cells means we can lose control over how our skin ages. Epidermal stem cells needed to create healthy new skin are significantly reduced and function less efficiently. A discovery based on promising plant stem cell research may allow you to regain control. Scientists have found that a novel extract derived from the stem cells of a rare apple tree cultivated for its extraordinary longevity shows tremendous ability to rejuvenate aging skin. By stimulating aging skin stem cells, this plant extract has been shown to lessen the appearance of unsightly wrinkles. Clinical trials show that this unique formulation increases the longevity of skin cells, resulting in skin that has a more youthful and radiant appearance. Stem Cells Cells in our bodies are programmed for specific functions. A skin cell, a brain cell, and a liver cell all contain the same DNA, or set of genes. However, each cell’s fate is determined by a set of epigenetic (able to change gene expression patterns) signals that come from inside it and from the surrounding cells as well. These signals are like command tags attached to the DNA that switch certain genes on or off. This selective coding creates all of the different kinds of cells in our bodies, which are collectively known as differentiated (specialized) cells. Stem Cells Although differentiated cells vary widely in purpose and appearance, they all have one thing in common: they all come with a built-in operational limit. After so many divisions, they lose their ability to divide and must be replaced. This is where stem cells come in. Your body also produces other cells that contain no specific programming. These stem cells are “blank,” so your body can essentially “format” them any way it pleases. Two universal aspects shared by this type of cell are: (1) the ability to replenish itself through a process of self-renewal and (2) the capacity to produce a differentiated cell. In animals and humans, two basic kinds of stem cells exist: embryonic and adult stem cells. Embryonic stem cells have the power to change into any differentiated cell type found anywhere in your body. Adult stem cells, on the other hand, are generally more limited. They can only evolve into the specific type of cell found in the tissue where they are located. The primary function of these adult stem cells is maintenance and repair. But certain adult stem cells found in nature retain the unlimited developmental potential that embryonic stem cells possess. These cells have become the main focus for an exciting new wave of regenerative medicine (repairing damaged or diseased tissues and organs using advanced techniques like stem cell therapy and tissue engineering). The Role of Stem Cells in the Skin The basal (innermost) layer of the skin’s epidermis comprises two basic types of cells: (1) the slowly dividing epidermal stem cells (that represent about 2-7% of the basal cell population) and (2) their rapidly dividing offspring that supply new cells to replace those that are lost or dying.1-3 The slow self-renewal process of epidermal stem cells, however, creates a problem. Because each epidermal stem cell only lasts for a certain number of divisions, and because each division runs the risk of lethal DNA mutation, the epidermal stem cell population can become depleted. When this happens, lost or dying skin cells begin to outnumber their replacements and the skin’s health and appearance start to decline. So what can be done? Scientists turned to plants for the answer. Planting a Seed of Hope Plants also have stem cells. Like humans, plant stem cells depend on epigenetic control and signals from surrounding cells for their development. Unlike humans, however, each plant-derived adult stem cell possesses the ability to generate a whole new plant.4 Scientists have found a way to harness the power of plant stem cells by growing plant tissues in culture. Planting a Seed of Hope The technique is a relatively simple one. First, viable tissue is obtained from a source plant. This material is called an explant. Next, a small cut is made in the explant. New cells form on the surface of this cut in an attempt to heal the wound. This colorless mass of cells is called a callus. The slowly dividing cells of a callus are undifferentiated cells that lack the characteristics of normal plant cells. They are essentially unprogrammed and full of potential. With this technology, it is theoretically possible to propagate any plant cell in a liquid culture, opening up a whole new realm of possibilities. This fact started scientists thinking—what would happen if an extract of genetically long-lived plant stem cell tissue was applied to human skin? Comparing Apples to Apples Today, apples are cultivated primarily to enhance their appearance and flavor. But before the rise of refrigeration, an apple’s ability to stay fresh for a long time was its most sought-after characteristic. For this reason, a special variety of apple was cultivated in the middle of the 18th century that could be stored for a greatly extended period of time. In essence, it was the genetically modified, longer-living stem cells of this tannin-rich variety of apple, called the Uttwiler Spätlauber apple, which were responsible for its unique storage longevity. In a certain isolated area of rural Switzerland, a few of these hardy apple trees still survive today. Scientists obtained an explant from the leaf of one of these trees to produce a special anti-aging stem cell extract. The Amazing Results In order to test the theory that this unique plant extract would produce anti-aging effects, scientists at Mibelle Biochemistry first obtained human stem cells from the blood of an umbilical cord. Their first in-house study on cell viability showed that, at a concentration of only 0.1%, an extract of Uttwiler Spätlauber stem cells stimulated the proliferation of human stem cells by an astounding 80%! 5 The Amazing Results In a second experiment, these scientists irradiated the umbilical cord blood stem cells with UV light. Nearly 50% of the stem cells cultured in growth medium alone died, but the cells grown in the culture containing the special apple extract showed only a small decrease in the number of living cells.5 Another in vitro experiment conducted by the scientists involved fibroblast cells. These are the most common of all cells in the connective tissue of the skin. They manufacture the collagen, glycosaminoglycans, reticular and elastic fibers, and glycoproteins that make up the extracellular matrix (connective tissues providing support to cells). Fibroblasts not only help provide a structural framework for the skin, they also play a critical role in wound healing. In their experiment, the scientists treated fibroblast cells with hydrogen peroxide for two hours until the cells began to show classic signs of aging. In scientific terms, this means that several genes essential for cell proliferation and growth were significantly down-regulated. However, after incubating these cells for 144 hours in a 2% Uttwiler Spätlauber extract, this down-regulation of genes was effectively neutralized, and in some cases, it was actually reversed! In addition, the scientists noted that the expression of an important antioxidant enzyme called heme oxigenase 1 was also stimulated.5
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